Predicting phenotypic and genotypic evolution given fluctuating selection
Aims
- Develop a polygenic model that accurately predicts genotypic and phenotypic evolution featuring fluctuating selection
Genome
- Phenotype is the sum of all allele’s effect plus random noise
Parameters
WF model with 5 replicates each having the following parameters:
- Heritability: 0.1, 0.5, and 0.8
- Loci numbers: 1, 10, 70, 100, 300
- Standard deviations: 1, 2, 3, 4
- Generation interval (GI): 10, 20, 30 (Linear changes)
- GI: sinusoidal1 (20) and sinusoidal2 (5, 10, 15, 30)
Fitness Function
\[
\text{Fitness} = \exp\left(-\frac{1}{{\text{phenotype}}} \times (\text{phenotype} - \text{optimum})^2\right)
\]
- Optimum = mean(phenotype) ± nSD
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Genotype file
| 1 |
543033 |
0.99725 |
0.756542 |
| 1 |
652860 |
0.99155 |
0.221580 |
| 1 |
713875 |
0.98910 |
0.189974 |
| 1 |
774890 |
0.98090 |
2.506406 |
| 1 |
1006747 |
0.97920 |
0.333771 |
| 1 |
445409 |
0.97905 |
0.022710 |
Phenotype file
| 1 |
0.911877 |
109.5748 |
112.614 |
| 2 |
0.912294 |
109.5830 |
112.614 |
| 3 |
0.915522 |
109.6475 |
112.614 |
| 4 |
0.923517 |
109.8138 |
112.614 |
| 5 |
0.926507 |
109.8774 |
112.614 |
| 6 |
0.918121 |
109.7005 |
112.614 |
Alle Frequency (single plot FS)
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Allele Frequency (single model)
Mean Allele Frequency (all variables)
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Phenotypes (single plot FS)
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Phenotypes (single model)
Phenotypes (all variables)
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Questions for the group
- How can I summarize the results to communicate parameters’ effect given all simulations?
- what I can change on the plots or which plots I should use to convey the information from simulation?
- Any other statistical analyses, apart from spectral analysis should I perform?
- Which biological questions should I ask?
